PDGFRβ-specific affibody-directed delivery of a photosensitizer, IR700, is efficient for vascular-targeted photodynamic therapy of colorectal cancer.

ABSTRACT: Vascular-targeted photodynamic therapy (PDT) is an important strategy for cancer therapy. Conventional vascular-targeted PDT has been achieved by passive photosensitizer (PS) delivery, which involves a high risk of adverse effects. Active PS delivery is urgently required for vascular-targeted PDT. Although endothelial cells and pericytes are major cellular components of tumor blood vessels, little attention has been paid to pericyte-targeted PDT for cancer therapy. PDGFRβ is abundantly expressed in the pericytes of various tumors. In this experiment, a dimeric Z_PDGFRβ affibody with a 0.9 nM affinity for PDGFRβ was produced. The Z_PDGFRβ affibody showed PDGFRβ-dependent pericyte binding. Intravenously injected Z_PDGFRβ affibody was predominantly distributed on

SUBMITTER: Shi Q 

PROVIDER: S-EPMC8240977 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature