Mathematical modeling of intraperitoneal drug delivery: simulation of drug distribution in a single tumor nodule.

ABSTRACT: The intraperitoneal (IP) administration of chemotherapy is an alternative treatment for peritoneal carcinomatosis, allowing for higher intratumor concentrations of the cytotoxic agent compared to intravenous administration. Nevertheless, drug penetration depths are still limited to a few millimeters. It is thus necessary to better understand the limiting factors behind this poor penetration in order to improve IP chemotherapy delivery. By developing a three-dimensional computational fluid dynamics (CFD) model for drug penetration in a tumor nodule, we investigated the impact of a number of key parameters on the drug transport and penetration depth during IP chemotherapy. Overall, smaller tumors showed better penetration than larger ones, which could be attributed to the lower IFP in smalle

SUBMITTER: Steuperaert M 

PROVIDER: S-EPMC8240979 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature