Lipid-based nanosystem of edaravone: development, optimization, characterization and in vitro/in vivo evaluation.

ABSTRACT: Edaravone (EDR) is a well-recognized lipophilic free radical scavenger for diseases including neurodegenerative disease, cardiovascular disease, and cancer. However, its oral use is restricted due to poor oral bioavailability (BA). The aim of present research was to enable its oral use by developing a lipid-based nanosystem (LNS). The components of LNS including oil, surfactants, and co-surfactants were selected based on their potential to maximize the solubilization in gastrointestinal (GI) fluids, reduce its glucuronidation and improve transmembrane permeability. The liquid LNS (L-LNS) with Capryol™ PGMC (Oil), Cremophor^® RH 40:Labrasol^®:TPGS 1000 (1:0.8:0.2) (Surfactant) and Transcutol P^® (Co-surfactant) were optimized to form microemulsion having drople

SUBMITTER: Parikh A 

PROVIDER: S-EPMC8241028 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature