Semaphorin 3E deficiency dysregulates dendritic cell functions: In vitro and in vivo evidence.

ABSTRACT: Regulation of dendritic cell functions is a complex process in which several mediators play diverse roles as a network in a context-dependent manner. The precise mechanisms underlying dendritic cell functions have remained to be addressed. Semaphorins play crucial roles in regulation of various cell functions. We previously revealed that Semaphorin 3E (Sema3E) contributes to regulation of allergen-induced airway pathology partly mediated by controlling recruitment of conventional dendritic cell subsets in vivo, though the underlying mechanism remained elusive. In this study, we investigate the potential regulatory role of Sema3E in dendritic cells. We demonstrated that bone marrow-derived dendritic cells differentiated from Sema3e-/- progenitors have an enhanced migration capacity both at

SUBMITTER: Movassagh H 

PROVIDER: S-EPMC8241044 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature