An injectable in situ gel with cubic and hexagonal nanostructures for local treatment of chronic periodontitis.

ABSTRACT: Periodontitis is a chronic bacterial infection, and its effective treatment is dependent on the retention of antibiotics of effective concentrations at the periodontal pockets. In this study, a solution-gel based inverse lyotropic liquid crystalline (LLC) system was explored to deliver metronidazole to the periodontal pockets for local treatment of periodontitis. It was found that the metronidazole-loaded LLC precursor spontaneously transformed into gel in the presence of water in the oral cavity. The low viscosity of the precursor would allow its penetration to the rather difficult to reach infection sites, while the adhesiveness and crystalline nanostructures (inverse bicontinuous cubic Pn3m phase and inverse hexagonal phase) of the formed gel would permit its firm adhesion to the period

SUBMITTER: Mei L 

PROVIDER: S-EPMC8241103 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature