Hierarchical pulmonary target nanoparticles via inhaled administration for anticancer drug delivery.

ABSTRACT: Inhalation administration, compared with intravenous administration, significantly enhances chemotherapeutic drug exposure to the lung tissue and may increase the therapeutic effect for pulmonary anticancer. However, further identification of cancer cells after lung deposition of inhaled drugs is necessary to avoid side effects on normal lung tissue and to maximize drug efficacy. Moreover, as the action site of the major drug was intracellular organelles, drug target to the specific organelle is the final key for accurate drug delivery. Here, we designed a novel multifunctional nanoparticles (MNPs) for pulmonary antitumor and the material was well-designed for hierarchical target involved lung tissue target, cancer cell target, and mitochondrial target. The biodistribution in vivo determin

SUBMITTER: Chen R 

PROVIDER: S-EPMC8241141 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature