A Network Architecture for Bidirectional Neurovascular Coupling in Rat Whisker Barrel Cortex.

ABSTRACT: Neurovascular coupling is typically considered as a master-slave relationship between the neurons and the cerebral vessels: the neurons demand energy which the vessels supply in the form of glucose and oxygen. In the recent past, both theoretical and experimental studies have suggested that the neurovascular coupling is a bidirectional system, a loop that includes a feedback signal from the vessels influencing neural firing and plasticity. An integrated model of bidirectionally connected neural network and the vascular network is hence required to understand the relationship between the informational and metabolic aspects of neural dynamics. In this study, we present a computational model of the bidirectional neurovascular system in the whisker barrel cortex and study the effect of such co

SUBMITTER: Kumar BS 

PROVIDER: S-EPMC8241226 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature