Intraoperative protective ventilation in patients undergoing major neurosurgical interventions: a randomized clinical trial.

ABSTRACT:

Background

Post-operative pulmonary complications (PPC) can develop in up to 13% of patients undergoing neurosurgical procedures and may adversely affect clinical outcome. The use of intraoperative lung protective ventilation (LPV) strategies, usually including the use of a low V_t, low PEEP and low plateau pressure, seem to reduce the risk of PPC and are strongly recommended in almost all surgical procedures. Nonetheless, feasibility of LPV strategies in neurosurgical patients are still debated because the use of low Vt during LPV might result in hypercapnia with detrimental effects on cerebrovascular physiology. Aim of our study was to determine whether LPV strategies would be feasible compared with a control group in adult patients undergoing cranial or spinal surgery.

SUBMITTER: Longhini F 

PROVIDER: S-EPMC8241565 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature