Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging.

ABSTRACT: Viruses must efficiently and specifically package their genomes while excluding cellular nucleic acids and viral subgenomic fragments. Some viruses use specific packaging signals, which are conserved sequence or structure motifs present only in the full-length genome. Recent work has shown that viral proteins important for packaging can undergo liquid-liquid phase separation (LLPS), in which one or two viral nucleic acid binding proteins condense with the genome. The compositional simplicity of viral components lends itself well to theoretical modeling compared with more complex cellular organelles. Viral LLPS can be limited to one or two viral proteins and a single genome that is enriched in LLPS-promoting features. In our previous study, we observed that LLPS-promoting sequences of sever

SUBMITTER: Seim I 

PROVIDER: S-EPMC8241574 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature