Mendelian randomization analysis identified genes potentially pleiotropically associated with periodontitis.

ABSTRACT:

Objective

To prioritize genes that were pleiotropically or potentially causally associated with periodontitis.

Methods

We applied the summary data-based Mendelian randomization (SMR) method integrating genome-wide association study (GWAS) for periodontitis and expression quantitative trait loci (eQTL) data to identify genes that were pleiotropically associated with periodontitis. We performed separate SMR analysis using CAGE eQTL data and GTEx eQTL data. SMR analysis were done for participants of European and East Asian ancestries, separately.

Results

We identified multiple genes showing pleiotropic association with periodontitis in participants of European ancestry and participants of East Asian ancestry. PDCD2 (corresponding probe: ILMN_1758915) was the top h

SUBMITTER: Wang F 

PROVIDER: S-EPMC8241609 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature