Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV.

ABSTRACT: Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such biomarkers can improve the safety of analytic treatment interruption (ATI) and provide mechanistic insights into the host pathways involved in post-ART HIV control. Here we report plasma glycomic and metabolic signatures of time-to-viral-rebound and probability-of-viral-remission using samples from two independent cohorts. These samples include a large number of post-treatment controllers, a rare population demonstrating sustained virologic suppression after ART-cessation. These signatures remain significant after adjusting for key demographic and clinical confounders. We also report mechanistic links between some of these biomarkers and HIV latency reactivation and/

SUBMITTER: Giron LB 

PROVIDER: S-EPMC8241829 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature