Insights into rumen microbial biosynthetic gene cluster diversity through genome-resolved metagenomics.

ABSTRACT: Ruminants are critical to global food security as they transform lignocellulosic biomass into high-quality protein products. The rumen microbes ferment feed to provide necessary energy and nutrients for the ruminant host. However, we still lack insight into the metabolic processes encoded by most rumen microbial populations. In this study, we implemented metagenomic binning approaches to recover 2,809 microbial genomes from cattle, sheep, moose, deer, and bison. By clustering genomes based on average nucleotide identity, we demonstrate approximately one-third of the metagenome-assembled genomes (MAGs) to represent species not present in current reference databases and rumen microbial genome collections. Combining these MAGs with other rumen genomic datasets permitted a phylogenomic charact

SUBMITTER: Anderson CL 

PROVIDER: S-EPMC8241843 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature