Real-time finite element analysis allows homogenization of tissue scale strains and reduces variance in a mouse defect healing model.

ABSTRACT: Mechanical loading allows both investigation into the mechano-regulation of fracture healing as well as interventions to improve fracture-healing outcomes such as delayed healing or non-unions. However, loading is seldom individualised or even targeted to an effective mechanical stimulus level within the bone tissue. In this study, we use micro-finite element analysis to demonstrate the result of using a constant loading assumption for all mouse femurs in a given group. We then contrast this with the application of an adaptive loading approach, denoted real time Finite Element adaptation, in which micro-computed tomography images provide the basis for micro-FE based simulations and the resulting strains are manipulated and targeted to a reference distribution. Using this approach, we demon

SUBMITTER: Paul GR 

PROVIDER: S-EPMC8241979 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature