The impact of myocardial compressibility on organ-level simulations of the normal and infarcted heart.

ABSTRACT: Myocardial infarction (MI) rapidly impairs cardiac contractile function and instigates maladaptive remodeling leading to heart failure. Patient-specific models are a maturing technology for developing and determining therapeutic modalities for MI that require accurate descriptions of myocardial mechanics. While substantial tissue volume reductions of 15-20% during systole have been reported, myocardium is commonly modeled as incompressible. We developed a myocardial model to simulate experimentally-observed systolic volume reductions in an ovine model of MI. Sheep-specific simulations of the cardiac cycle were performed using both incompressible and compressible tissue material models, and with synchronous or measurement-guided contraction. The compressible tissue model with measurement-gu

SUBMITTER: Liu H 

PROVIDER: S-EPMC8242073 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature