Co-Occurring Potentially Actionable Oncogenic Drivers in Non-Small Cell Lung Cancer.

ABSTRACT:

Background

Several oncogenic drivers in non-small cell lung cancer (NSCLC) are considered actionable with available or promising targeted therapies. Although targetable drivers rarely overlap with each other, there were a minority of patients harboring co-occurring actionable oncogenic targets, whose clinical characteristics and prognosis are not yet clear.

Methods

A total of 3,077 patients with NSCLC who underwent molecular analysis by NGS were included, and their demographic and clinical data were retrospectively collected.

Results

Our study found that the frequency of NSCLC patients harboring co-occurring potentially actionable alterations was approximately 1.5% (46/3077); after excluding patients with EGFR-undetermined mutations, the incidence was 1.3% (40/

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC8242190 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature