Bifidobacterium breve Exopolysaccharide Blocks Dendritic Cell Maturation and Activation of CD4⁺ T Cells.

ABSTRACT: Exopolysaccharide (EPS) is a bacterial extracellular carbohydrate moiety which has been associated with immunomodulatory activity and host protective effects of several gut commensal bacteria. Bifidobacterium breve are early colonizers of the human gastrointestinal tract (GIT) but the role of EPS in mediating their effects on the host has not been investigated for many strains. Here, we characterized EPS production by a panel of human B. breve isolates and investigated the effect of EPS status on host immune responses using human and murine cell culture-based assay systems. We report that B. breve EPS production is heterogenous across strains and that immune responses in human THP-1 monocytes are strain-specific, but not EPS status-specific. Using wild type and isogeni

SUBMITTER: Hickey A 

PROVIDER: S-EPMC8242212 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature