The evolutionary dynamics of viruses: virion release strategies, time delays and fitness minima.

ABSTRACT: Viruses exhibit a diverse array of strategies for infecting host cells and for virion release after replication. Cell exit strategies generally involve either budding from the cell membrane or killing the host cell. The conditions under which either is at a selective advantage is a key question in the evolutionary theory of viruses, with the outcome having potentially important impacts on the course of infection and pathogenicity. Although a plethora of external factors will influence the fitness of either strategy; here, we focus just on the effects of the physical properties of the system. We develop theoretical approaches to assess the effects of the time delays between initial infection and virion release. We show that the length of the delay before apoptosis is an important trait in v

SUBMITTER: Lord JS 

PROVIDER: S-EPMC8242231 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature