NKG2D Enhances Double-Negative T Cell Regulation of B Cells.

ABSTRACT: Numerous studies reported a small subpopulation of TCRαβ⁺CD4^-CD8^- (double-negative) T cells that exert regulatory functions in the peripheral lymphocyte population. However, the origin of these double-negative T (DNT) cells is controversial. Some researchers reported that DNT cells originated from the thymus, and others argued that these cells are derived from peripheral immune induction. We report a possible mechanism for the induction of nonregulatory CD4⁺ T cells to become regulatory double-negative T (iDNT) cells in vitro. We found that immature bone marrow dendritic cells (CD86⁺MHC-II^- DCs), rather than mature DCs (CD86⁺MHC-II⁺), induced high levels of iDNT cells. The addition of an anti-MHC

SUBMITTER: Hu SH 

PROVIDER: S-EPMC8242353 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature