An international comparison of anti-SARS-COV-2 assays used for seroprevalence surveys from blood component providers.

ABSTRACT:

Background and objectives

Access to large pools of healthy adult donors advantageously positions blood component providers to undertake anti-SARS-CoV-2 seroprevalence studies. While numerous seroprevalence reports have been published by blood operators during the COVID-19 pandemic, details on the assay used has not been well documented. The objectives of this study were to evaluate the diversity of assays being used by blood operators and assess how this may affect seroprevalence estimates.

Materials and methods

We surveyed 49 blood component providers from 39 countries. Questionnaire included information on the number and identity of assays used, the detected immunoglobulin(s) and target antigen, and performance characteristics (sensitivity, specificity).

Results

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SUBMITTER: Lewin A 

PROVIDER: S-EPMC8242559 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature