Trichosporon asahii superinfections in critically ill COVID-19 patients overexposed to antimicrobials and corticosteroids.

ABSTRACT:

Objectives

To investigate the occurrence of Trichosporon asahii fungemia among critically ill COVID-19 patients.

Methods

From 1 July to 30 September 2020, cases of T asahii fungemia (TAF) in a Brazilian COVID-19 referral centre were investigated. The epidemiology and clinical courses were detailed, along with a mycological investigation that included molecular species identification, haplotype diversity analysis and antifungal susceptibility testing.

Results

Five critically ill COVID-19 patients developed TAF in the period. All five patients had common risk conditions for TAF: central venous catheter at fungemia, previous exposure to broad-spectrum antibiotics, prior echinocandin therapy and previous prolonged corticosteroid therapy. The average time of intensive care

SUBMITTER: Nobrega de Almeida J 

PROVIDER: S-EPMC8242571 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature