Complement levels at admission as a reflection of coronavirus disease 2019 (COVID-19) severity state.

ABSTRACT: Complement system hyperactivation has been proposed as a potential driver of adverse outcomes in severe acute respiratory syndrome coronavirus 2 infected patients, given prior research of complement deposits found in tissue and blood samples, as well as evidence of clinical improvement with anticomplement therapy. Its role in augmenting thrombotic microangiopathy mediated organ damage has also been implicated in coronavirus disease 2019 (COVID-19). This study aimed to examine associations between complement parameters and progression to severe COVID-19 illness, as well as correlations with other systems. Blood samples of COVID-19 patients presenting to the emergency department (ED) were analyzed for a wide panel of complement and inflammatory biomarkers. The primary outcome was COVID-19 se

SUBMITTER: Henry BM 

PROVIDER: S-EPMC8242600 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature