Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin.

ABSTRACT: The immune response plays a critical role in the pathophysiology of SARS-CoV-2 infection ranging from protection to tissue damage and all occur in the development of acute respiratory distress syndrome (ARDS). ARDS patients display elevated levels of inflammatory cytokines and innate immune cells, and T and B cell lymphocytes have been implicated in this dysregulated immune response. Mast cells are abundant resident cells of the respiratory tract and are able to release different inflammatory mediators rapidly following stimulation. Recently, mast cells have been associated with tissue damage during viral infections, but their role in SARS-CoV-2 infection remains unclear. In this study, we examined the profile of mast cell activation markers in the serum of COVID-19 patients. We noticed th

SUBMITTER: Soria-Castro R 

PROVIDER: S-EPMC8242632 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature