Tracing genetic signatures of bat-to-human coronaviruses and early transmission of North American SARS-CoV-2.

ABSTRACT: Highly pathogenic coronaviruses, including SARS-CoV-2, SARS-CoV and MERS-CoV, are thought to be transmitted from bats to humans, but the viral genetic signatures that contribute to bat-to-human transmission remain largely obscure. In this study, we identified an identical ribosomal frameshift motif among the three bat-human pairs of viruses and strong purifying selection after jumping from bats to humans. This represents genetic signatures of coronaviruses that are related to bat-to-human transmission. To further trace the early human-to-human transmission of SARS-CoV-2 in North America, a geographically stratified genome-wide association study (North American isolates and the remaining isolates) and a retrospective study were conducted. We determined that the single nucleotide polymorphis

SUBMITTER: Ou X 

PROVIDER: S-EPMC8242746 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature