Treg-inducing capacity of genomic DNA of <i>Bifidobacterium longum</i> subsp. <i>infantis</i>.

ABSTRACT: Background: Allergic and autoimmune diseases comprise a group of inflammatory disorders caused by aberrant immune responses in which CD25⁺ forkhead box P3-positive regulatory T cells (Treg) cells that normally suppress inflammatory events are often poorly functioning. This has stimulated an intensive investigative effort to find ways of increasing Tregs as a method of therapy for these conditions. Commensal microbiota known to have health benefits in humans include the lactic acid-producing, probiotic bacteria B. longum subsp. infantis and Lactobacillus rhamnosus. Mechanistically, several mechanisms have been proposed to explain how probiotics may favorably affect host immunity, including the induction of Tregs. Analysis of emerging data from several laboratories,

SUBMITTER: Li D 

PROVIDER: S-EPMC8242987 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature