Ontology highlight
ABSTRACT:
SUBMITTER: Ye ZH
PROVIDER: S-EPMC8243019 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Ye Zi-Han ZH Jiang Xiao-Ming XM Huang Mu-Yang MY Xu Yu-Lian YL Chen Yu-Chi YC Yuan Luo-Wei LW Huang Can-Yu CY Yu Wei-Bang WB Chen Xiuping X Lu Jin-Jian JJ
Translational oncology 20210623 9
The anti-phagocytosis signal, CD47, prevents phagocytosis when it interacts with signal-regulatory protein alpha (SIRPα) on macrophages. Given the vital role of CD47 in immune response, further investigation on the regulation of CD47 in tumor microenvironment is needed. Herein, we identified that interferon-gamma (IFN-γ), one of the most important cytokines in the immune and inflammatory response, up-regulated CD47 expression in cancer cells and this effect could be inhibited by the JAK1/2 inhib ...[more]