Association of Murine Double Minute 2 polymorphisms with gastric cancer: A systematic review with meta-analysis.

ABSTRACT: Gastric cancer (GC) is the 5th most common type of cancer, with the 3rd highest mortality rate worldwide in both sexes. Murine double minute 2 (MDM2) protein is the major negative regulator of p53, and genetic polymorphisms in this gene have shown to be associated with several types of cancer. In the present study, a literature search was performed using PubMed and Scopus with the following key word combinations 'gastric cancer AND polymorphism AND MDM2'. Studies were carefully revised according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify eligible studies that matched the inclusion criteria. Statistical analysis was performed to assess the association between the different genetic polymorphisms and GC risk, by calculating the odds ratios

SUBMITTER: Timoteo M 

PROVIDER: S-EPMC8243240 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature