Scope and heterogeneity of outcomes reported in randomized trials in patients receiving peritoneal dialysis.

ABSTRACT:

Background

Randomized trials can provide evidence to inform decision-making but this may be limited if the outcomes of importance to patients and clinicians are omitted or reported inconsistently. We aimed to assess the scope and heterogeneity of outcomes reported in trials in peritoneal dialysis (PD).

Methods

We searched the Cochrane Kidney and Transplant Specialized Register for randomized trials in PD. We extracted all reported outcome domains and measurements and analyzed their frequency and characteristics.

Results

From 128 reports of 120 included trials, 80 different outcome domains were reported. Overall, 39 (49%) domains were surrogate, 23 (29%) patient-reported and 18 (22%) clinical. The five most commonly reported domains were PD-related infection [59 (49%)

SUBMITTER: Manera KE 

PROVIDER: S-EPMC8243273 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature