Hyperkalemia excursions are associated with an increased risk of mortality and hospitalizations in hemodialysis patients.

ABSTRACT:

Background

Hyperkalemia is common among hemodialysis (HD) patients and has been associated with adverse clinical outcomes. Previous studies considered a single serum potassium (K) measurement or time-averaged values, but serum K excursions out of the target range may be more reflective of true hyperkalemia events. We assessed whether hyperkalemia excursions lead to an elevated risk of adverse clinical outcomes.

Methods

Using data from 21 countries in Phases 4-6 (2009-18) of the Dialysis Outcomes and Practice Patterns Study (DOPPS), we investigated the associations between peak serum K level, measured monthly predialysis, over a 4-month period ('peak K') and clinical outcomes over the subsequent 4 months using Cox regression, adjusted for potential confounders.

Results

SUBMITTER: Karaboyas A 

PROVIDER: S-EPMC8243282 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature