Progressive loss of implant fixation in a preclinical rat model of cemented knee arthroplasty.

ABSTRACT: Aseptic loosening of total knee arthroplasty continues to be a challenging clinical problem. The progression of the loosening process, from the initial well-fixed component, is not fully understood. In this study, loss of fixation of cemented hemiarthroplasty was explored using 9-month-old Sprague-Dawley rats with 0, 2, 6, 12, 26 week end points. Morphological and cellular changes of cement-bone fixation were determined for regions directly below the tibial tray (epiphysis) and distal to the tray (metaphysis). Loss of fixation, with a progressive increase in cement-bone gap volume was found in the epiphysis (0.162  mm³ /week), but did not progress appreciably in the metaphysis (0.007 mm³ /week). In the epiphysis, there was an early and sustained elevation of osteoclas

SUBMITTER: Mann KA 

PROVIDER: S-EPMC8243390 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature