Metabolic and immunological phenotype of rare lipomatoses: Dercum's disease and Roch-Leri mesosomatic lipomatosis.

ABSTRACT:

Context

Dercum's disease (DD) and Roch-Leri mesosomatic lipomatosis (LMS) are rare and poorly characterized diseases. The clinical presentation combines multiple lipomas, painful in DD in contrast with LMS, without lipoatrophy.

Objective

To identify any specific metabolic and immune phenotype of DD and LMS.

Design and patients

This monocentric retrospective study included 46 patients: 9 DD, 11 LMS, 18 lean and 8 obese controls. Metabolic and immunohematological characteristics of each group were compared.

Results

The median age of the patients was similar in the 3 groups (31 years). The number of women, and of basophils, and CD3⁺, CD4⁺ and CD8⁺ T lymphocytes was significantly higher in the DD versus the LMS group, without any di

SUBMITTER: Lemaitre M 

PROVIDER: S-EPMC8243498 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature