T-cell receptor-based therapy: an innovative therapeutic approach for solid tumors.

ABSTRACT: T-cell receptor (TCR)-based adoptive therapy employs genetically modified lymphocytes that are directed against specific tumor markers. This therapeutic modality requires a structured and integrated process that involves patient screening (e.g., for HLA-A*02:01 and specific tumor targets), leukapheresis, generation of transduced TCR product, lymphodepletion, and infusion of the TCR-based adoptive therapy. In this review, we summarize the current technology and early clinical development of TCR-based therapy in patients with solid tumors. The challenges of TCR-based therapy include those associated with TCR product manufacturing, patient selection, and preparation with lymphodepletion. Overcoming these challenges, and those posed by the immunosuppressive microenvironment, as well as develop

SUBMITTER: Tsimberidou AM 

PROVIDER: S-EPMC8243554 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature