Searching for Novel Candidate Biomarkers of RLS in Blood by Proteomic Analysis.

ABSTRACT:

Purpose

We performed comparative proteomic analyses of blood of patients with RLS and healthy individuals aiming to identify potential biomarker and therapeutic target candidate for RLS.

Patients and methods

Blood serum samples from 12 patients with a clinical diagnosis of RLS (8 females and 4 males, with a mean age of 68.52 years) and 10 healthy controls (5 females and 5 males, with a mean age of 67.61 years) underwent proteomic profiling by liquid chromatography coupled with tandem mass spectrometry. Pathway analysis incorporating protein-protein interaction networks was carried out to identify pathological processes linked to the differentially expressed proteins.

Results

We quantified 272 proteins in patients with RLS and healthy controls, of which 243 were shared

SUBMITTER: Mondello S 

PROVIDER: S-EPMC8243594 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature