Identification of potential hub genes associated with skin wound healing based on time course bioinformatic analyses.

ABSTRACT:

Background

The skin is the largest organ of the body and has multiple functions. Wounds remain a significant healthcare problem due to the large number of traumatic and pathophysiological conditions patients suffer.

Methods

Gene expression profiles of 37 biopsies collected from patients undergoing split-thickness skin grafts at five different time points were downloaded from two datasets (GSE28914 and GSE50425) in the Gene Expression Omnibus (GEO) database. Principal component analysis (PCA) was applied to classify samples into different phases. Subsequently, differentially expressed genes (DEGs) analysis, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway functional enrichment analyses were performed, and protein-protein interaction (PPI) networks

SUBMITTER: Zhu HJ 

PROVIDER: S-EPMC8243612 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature