Histological Markers of Clinical Relapse in Endoscopically Quiescent Ulcerative Colitis.

ABSTRACT:

Background

In ulcerative colitis (UC) patients who have achieved mucosal healing, active microscopic colonic mucosal inflammation is commonly observed. We aimed to assess the association between histological activity and disease relapse in endoscopically quiescent UC.

Methods

Ulcerative colitis patients with endoscopically quiescent disease and ≥12 months of follow-up were included. Biopsies were reviewed for the presence of basal plasmacytosis (BPC) and active histological inflammation, defined as a Geboes score (GS) ≥3.2. Primary outcome measures were disease relapse at 18 months and time to first relapse after index colonoscopy.

Results

Seventy-six UC patients (51% male; mean age, 38.6 years; median follow-up [range], 75.2 [2-118] months) were included. Sixty-two p

SUBMITTER: Kevans D 

PROVIDER: S-EPMC8243631 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature