Biocompatibility, uptake and subcellular localization of bacterial magnetosomes in mammalian cells.

ABSTRACT: Magnetosomes represent biogenic, magnetic nanoparticles biosynthesized by magnetotactic bacteria. Subtle biological control on each step of biomineralization generates core-shell nanoparticles of high crystallinity, strong magnetization and uniform shape and size. These features make magnetosomes a promising alternative to chemically synthesized nanoparticles for many applications in the biotechnological and biomedical field, such as their usage as biosensors in medical diagnostics, as drug-delivery agents, or as contrast agents for magnetic imaging techniques. Thereby, the particles are directly applied to mammalian cells or even injected into the body. In the present work, we provide a comprehensive characterization of isolated magnetosomes as potential cytotoxic effects and particle upt

SUBMITTER: Mickoleit F 

PROVIDER: S-EPMC8243654 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature