Comparing the Rate of Nicotine Metabolism Among Smokers With Current or Past Major Depressive Disorder.

ABSTRACT:

Background and objectives

Persons with current or past major depressive disorder (MDD) vs those without have higher smoking rates. The nicotine metabolite ratio (NMR) represents variation in the rate of nicotine metabolism and has been associated with smoking behaviors and response to tobacco treatments. We compared NMR between smokers with current or past MDD (MDD+) vs smokers without MDD (MDD-). We also assessed correlates of NMR and compared withdrawal and craving between MDD+ and MDD- smokers.

Methods

Using baseline data from two clinical trials and propensity score weighting based on sex, race, body mass index, and smoking rate, we compared NMR between MDD+ (N = 279) and MDD- (N = 1575) smokers. We also compared groups on and nicotine withdrawal and craving.

Results<

SUBMITTER: Schnoll R 

PROVIDER: S-EPMC8243789 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature