Incident obstructive lung disease and mortality among people with HIV and a history of injecting drugs.

ABSTRACT:

Objective

People with HIV (PWH) experience increased prevalence of obstructive lung disease (OLD), regardless of greater observed smoking behaviors. We investigated whether the effect of incident OLD on mortality differed by HIV and HIV viral suppression among persons who inject drugs (PWID) and report smoking history.

Design

ALIVE is a longitudinal, observational cohort study of HIV-positive and seronegative PWID. This analysis included participants who had at least one spirometry measure to assess OLD between 2007 and 2016, excluding those who never smoked (5%, n = 62) or had baseline OLD (17%, n = 269).

Methods

Incident OLD occurred when the first prebronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) less than 0.70 during follo

SUBMITTER: Kalmin MM 

PROVIDER: S-EPMC8243832 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature