Role of pharmacogenomics in T-cell hypersensitivity drug reactions.

ABSTRACT:

Purpose of review

An update of the pharmacogenetic risk factors associated with T-cell-mediated delayed hypersensitivity reactions.

Recent findings

Recent HLA associations relevant to our understanding of immunopathogenesis and clinical practice include HLA-B∗13:01 with co-trimoxazole-induced SCAR, and HLA-A∗32:01 with vancomycin-DRESS, for which an extended HLA class II haplotype is implicated in glycopeptide antibiotic cross-reactivity. Hypoactive variants of ERAP1, an enzyme-trimming peptide prior to HLA loading, are now associated with protection from abacavir-hypersensitivity in HLA-B∗57:01+ patients, and single-cell sequencing has defined the skin-restricted expansion of a single, public and drug-reactive dominant TCR across patients with HLA-B∗15:02-restricted carbama

SUBMITTER: Hertzman RJ 

PROVIDER: S-EPMC8243836 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature