High intensity aerobic exercise improves bimanual coordination of grasping forces in Parkinson's disease.

ABSTRACT:

Introduction

Parkinson's disease (PD) disrupts the control and coordination of grasping forces, likely due to a disruption in basal ganglia circuitry and diminished activity within the supplementary motor area (SMA). High intensity aerobic exercise has been shown to enhance connectivity between basal ganglia nuclei and cortical areas, including the SMA. The aim of this project was to determine the effects of high intensity lower extremity exercise on motor control patterns underlying a manual dexterity task.

Methods

PD participants completed eight weeks of high intensity aerobic exercise under forced or voluntary exercise (FE or VE) modalities. Grasping forces for each limb were quantified during a functional bimanual dexterity task. Data were collected while OFF antiparkins

SUBMITTER: Jansen AE 

PROVIDER: S-EPMC8243853 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature