Dataset Information

Fast and accurate modeling of transient-state, gradient-spoiled sequences by recurrent neural networks.

ABSTRACT: Fast and accurate modeling of MR signal responses are typically required for various quantitative MRI applications, such as MR fingerprinting. This work uses a new extended phase graph (EPG)-Bloch model for accurate simulation of transient-state, gradient-spoiled MR sequences, and proposes a recurrent neural network (RNN) as a fast surrogate of the EPG-Bloch model for computing large-scale MR signals and derivatives. The computational efficiency of the RNN model is demonstrated by comparisons with other existing models, showing one to three orders of acceleration compared with the latest GPU-accelerated, open-source EPG package. By using numerical and in vivo brain data, two used cases, namely, MRF dictionary generation and optimal experimental design, are also provided. Results show that the RNN surrogate model can be efficiently used for computing large-scale dictionaries of transient-state signals and derivatives within tens of seconds, resulting in several orders of magnitude acceleration with respect to state-of-the-art implementations. The practical application of transient-state quantitative techniques can therefore be substantially facilitated.

SUBMITTER: Liu H

PROVIDER: S-EPMC8244023 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Fast and accurate modeling of transient-state, gradient-spoiled sequences by recurrent neural networks.

Liu Hongyan H van der Heide Oscar O van den Berg Cornelis A T CAT Sbrizzi Alessandro A

NMR in biomedicine 20210505 7

Fast and accurate modeling of MR signal responses are typically required for various quantitative MRI applications, such as MR fingerprinting. This work uses a new extended phase graph (EPG)-Bloch model for accurate simulation of transient-state, gradient-spoiled MR sequences, and proposes a recurrent neural network (RNN) as a fast surrogate of the EPG-Bloch model for computing large-scale MR signals and derivatives. The computational efficiency of the RNN model is demonstrated by comparisons wi ...[more]

PMID: 33949718

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Project description:Linear motifs mediate a wide variety of cellular functions, which makes their characterization in protein sequences crucial to understanding cellular systems. However, the short length and degenerate nature of linear motifs make their discovery a difficult problem. Here, we introduce MotifHound, an algorithm particularly suited for the discovery of small and degenerate linear motifs. MotifHound performs an exact and exhaustive enumeration of all motifs present in proteins of interest, including all of their degenerate forms, and scores the overrepresentation of each motif based on its occurrence in proteins of interest relative to a background (e.g., proteome) using the hypergeometric distribution. To assess MotifHound, we benchmarked it together with state-of-the-art algorithms. The benchmark consists of 11,880 sets of proteins from S. cerevisiae; in each set, we artificially spiked-in one motif varying in terms of three key parameters, (i) number of occurrences, (ii) length and (iii) the number of degenerate or "wildcard" positions. The benchmark enabled the evaluation of the impact of these three properties on the performance of the different algorithms. The results showed that MotifHound and SLiMFinder were the most accurate in detecting degenerate linear motifs. Interestingly, MotifHound was 15 to 20 times faster at comparable accuracy and performed best in the discovery of highly degenerate motifs. We complemented the benchmark by an analysis of proteins experimentally shown to bind the FUS1 SH3 domain from S. cerevisiae. Using the full-length protein partners as sole information, MotifHound recapitulated most experimentally determined motifs binding to the FUS1 SH3 domain. Moreover, these motifs exhibited properties typical of SH3 binding peptides, e.g., high intrinsic disorder and evolutionary conservation, despite the fact that none of these properties were used as prior information. MotifHound is available (http://michnick.bcm.umontreal.ca or http://tinyurl.com/motifhound) together with the benchmark that can be used as a reference to assess future developments in motif discovery.

Dataset Information

Fast and accurate modeling of transient-state, gradient-spoiled sequences by recurrent neural networks.

Publications

Fast and accurate modeling of transient-state, gradient-spoiled sequences by recurrent neural networks.

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