Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure.

ABSTRACT:

Aim

We have reported earlier that a high salt intake triggered an aestivation-like natriuretic-ureotelic body water conservation response that lowered muscle mass and increased blood pressure. Here, we tested the hypothesis that a similar adaptive water conservation response occurs in experimental chronic renal failure.

Methods

In four subsequent experiments in Sprague Dawley rats, we used surgical 5/6 renal mass reduction (5/6 Nx) to induce chronic renal failure. We studied solute and water excretion in 24-hour metabolic cage experiments, chronic blood pressure by radiotelemetry, chronic metabolic adjustment in liver and skeletal muscle by metabolomics and selected enzyme activity measurements, body Na⁺ , K⁺ and water by dry ashing, and acute transepid

SUBMITTER: Kovarik JJ 

PROVIDER: S-EPMC8244025 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature