Role of long non-coding RNAs in adipogenesis: State of the art and implications in obesity and obesity-associated diseases.

ABSTRACT: Obesity is an evolutionary, chronic, and relapsing disease that consists of a pathological accumulation of adipose tissue able to increase morbidity for high blood pressure, type 2 diabetes, metabolic syndrome, and obstructive sleep apnea in adults, children, and adolescents. Despite intense research over the last 20 years, obesity remains today a disease with a complex and multifactorial etiology. Recently, long non-coding RNAs (lncRNAs) are emerging as interesting new regulators as different lncRNAs have been found to play a role in early and late phases of adipogenesis and to be implicated in obesity-associated complications onset. In this review, we discuss the most recent advances on the role of lncRNAs in adipocyte biology and in obesity-associated complications. Indeed, more and mor

SUBMITTER: Rey F 

PROVIDER: S-EPMC8244036 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature