Empiric vs screening-based use of isoniazid for tuberculosis prophylaxis: Safety and effectiveness in lung transplant recipients in Saudi Arabia.

ABSTRACT:

Background

Tuberculosis (TB) is a major complication following transplantation. The likelihood of TB may be increased in transplant patients living in TB-endemic areas such as Saudi Arabia. In areas where TB is less common, guidelines recommend isoniazid (INH) for TB prophylaxis depending on patient and donor screening results. However, in TB-endemic regions, studies have supported its use in all transplant patients regardless of TB screening results. This study aimed to compare the safety and effectiveness of administering INH prophylaxis therapy based on the TB screening results of lung transplant (LT) recipients.

Methods

We conducted a single-center retrospective cohort study on LT recipients. The outcomes were compared between patients who were administered screening-bas

SUBMITTER: Korayem GB 

PROVIDER: S-EPMC8244089 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature