Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han population.

ABSTRACT:

Objectives

To evaluate the relationship between transcription factor 7-like 2 (TCF7L2) gene polymorphism and diabetic nephropathy (DN) risk, as well as the effect of gene-environment interactions on DN risk in Chinese Han population.

Methods

The Hardy-Weinberg equilibrium (HWE) and the relationship between TCF7L2 gene single nucleotide polymorphism (SNPs) and DN susceptibility were evaluated by SNPStats. The interaction among four SNPs and environmental factors were tested by generalized multifactor dimensionality reduction (GMDR). The consistency of cross validation, accuracy of test balance and sign test were calculated to evaluate the interaction of each selection. The logistic regression was used to test the interaction between rs7903146 and current smoking by stratified

SUBMITTER: Xue P 

PROVIDER: S-EPMC8244137 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature