Honeysuckle-derived microRNA2911 inhibits tumor growth by targeting TGF-β1.

ABSTRACT:

Background

Honeysuckle is a time-honored herb with anticancer activity in traditional Chinese medicine. Recently, accumulating reports are suggesting that the microRNAs in this medicinal plant not only play a physiological role in their original system, but also can be transmitted to another species as potential therapeutic components. In the numerous bioactive investigations, the anti-tumor effects of these microRNAs in the magical herb are rarely studied, especially the special miR2911, a honeysuckle-encoded atypical microRNA, with high stability during the boiling process and unique biological activity to target TGF-β1 mRNA.

Methods

Luciferase assay was conducted to test the ability of miR2911 to target TGF-β1 mRNA. ELISA was performed to determine the expression level of

SUBMITTER: Liu C 

PROVIDER: S-EPMC8244210 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature