The association between early impairment in cerebral autoregulation and outcome in a pediatric swine model of cardiac arrest.

ABSTRACT:

Aims

Evaluate cerebral autoregulation (CAR) by intracranial pressure reactivity index (PRx) and cerebral blood flow reactivity index (CBFx) during the first four hours following return of spontaneous circulation (ROSC) in a porcine model of pediatric cardiac arrest. Determine whether impaired CAR is associated with neurologic outcome.

Methods

Four-week-old swine underwent seven minutes of asphyxia followed by ventricular fibrillation induction and hemodynamic-directed CPR. Those achieving ROSC had arterial blood pressure, intracranial pressure (ICP), and microvascular cerebral blood flow (CBF) monitored for 4 h. Animals were assigned an 8 -h post-ROSC swine cerebral performance category score (1 = normal; 2-4=abnormal neurologic function). In this secondary analytic study, w

SUBMITTER: Kirschen MP 

PROVIDER: S-EPMC8244245 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature