Decidualization score identifies an endometrial dysregulation in samples from women with recurrent pregnancy losses and unexplained infertility.

ABSTRACT:

Objective

To study decidualization-associated endometrial factors.

Design

Retrospective cohort study to compare endometrial gene expression patterns in women experiencing reproductive failure including recurrent pregnancy loss or unexplained infertility versus fertile controls.

Setting

University Reproductive Medicine Center.

Patients

Women experiencing recurrent reproductive failure including recurrent pregnancy loss or unexplained infertility (n = 42) and fertile controls (n = 18).

Interventions

Endometrial biopsy samples were analyzed with targeted ribonucleic acid sequencing via next-generation sequencing.

Main outcome measures

The primary end point measurements were the expression of genes important for endometrial transformation during decid

SUBMITTER: Dambaeva S 

PROVIDER: S-EPMC8244268 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature