The physiologic response to rescue therapy with vasopressin versus epinephrine during experimental pediatric cardiac arrest.

ABSTRACT:

Aim

Compare vasopressin to a second dose of epinephrine as rescue therapy after ineffective initial doses of epinephrine in diverse models of pediatric in-hospital cardiac arrest.

Methods

67 one- to three-month old female swine (10-30 kg) in six experimental cohorts from one laboratory received hemodynamic-directed CPR, a resuscitation method where high quality chest compressions are provided and vasopressor administration is titrated to coronary perfusion pressure (CoPP) ≥20 mmHg. Vasopressors are given when CoPP is <20 mmHg, in sequences of two doses of 0.02 mg/kg epinephrine separated by minimum one-minute, then a rescue dose of 0.4 U/kg vasopressin followed by minimum two-minutes. Invasive measurements were used to evaluate and compare the hemodynamic and neurologic effe

SUBMITTER: Slovis JC 

PROVIDER: S-EPMC8244440 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature