The variation among sites of protein structure divergence is shaped by mutation and scaled by selection.

ABSTRACT: Protein structures do not evolve uniformly, but the degree of structure divergence varies among sites. The resulting site-dependent structure divergence patterns emerge from a process that involves mutation and selection, which may both, in principle, influence the emergent pattern. In contrast with sequence divergence patterns, which are known to be mainly determined by selection, the relative contributions of mutation and selection to structure divergence patterns is unclear. Here, studying 6 protein families with a mechanistic biophysical model of protein evolution, we untangle the effects of mutation and selection. We found that even in the absence of selection, structure divergence varies from site to site because the mutational sensitivity is not uniform. Selection scales the profile

SUBMITTER: Marcos ML 

PROVIDER: S-EPMC8244499 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature