Docosahexaenoic acid-mediated, targeted and sustained brain delivery of curcumin microemulsion.

ABSTRACT: We disclose microemulsions (ME) of curcumin (CUR) with docosahexaenoic acid (DHA)-rich oil (CUR DHA ME) for targeted delivery to the brain. MEs of CUR (5 mg/mL) with and without DHA-rich oil (CUR Capmul ME) suitable for intravenous and intranasal administration exhibited negative zeta potential, globule size  <20 nm and good stability. Following intravenous delivery MEs exhibited high brain concentration with CUR DHA ME exhibiting a 2.8-fold higher C_max than CUR solution. Furthermore, high and sustained concentration was demonstrated even at 24 h, which was 8- and 2-fold higher than CUR solution and CUR Capmul ME, respectively. Brain concentrations following intranasal administration were, however, substantially higher as evident from higher C_max and AUC and sustained

SUBMITTER: Shinde RL 

PROVIDER: S-EPMC8244623 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature